OTUD5 regulates p53 stability by deubiquitinating p53.

OTUD5 regulates p53 stability by deubiquitinating p53.

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The bostik mvp p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells.The stability of p53 is tightly regulated by ubiquitin-dependent degradation, driven mainly by its negative regulators ubiquitin ligase MDM2.In this study, we have identified OTUD5 as a DUB that interacts with and deubiquitinates p53.

OTUD5 forms a direct complex with p53 and controls level of ubiquitination.The function of OTUD5 is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress.As a novel deubiquitinating enzyme for p53, OTUD5 lightemupsequences.com is required for the stabilization and the activation of a p53 response.